ABSTRACT
La pitiriasis liquenoide crónica (PLC) es una enfermedad benigna, que se caracteriza por tener un curso gradual, con aparición de múltiples pápulas con escamas adherentes de predominio en tronco y extremidades proximales. Con el objetivo de describir la presentación clínica, discutir el diagnóstico, diagnósticos diferenciales, tratamiento y revisar la literatura se presenta el caso de un hombre de 88 años que presentó múltiples lesiones papuloescamosas en extremidades inferiores. Se realizó biopsia cutánea que confirmó el diagnóstico de PLC. El paciente recibió tratamiento con emulsión hidratante, clobetasol tópico y claritromicina con resolución completa de las lesiones. La pitiriasis liquenoide crónica es un trastorno inflamatorio poco frecuente, de etiología desconocida que ocurre más comúnmente en adultos jóvenes y niños. Si bien la clínica es sugerente, se requiere biopsia cutánea para su confirmación diagnóstica. Es un trastorno benigno, a menudo asintomático y autolimitado, por lo que se debe valorar su tratamiento paciente a paciente. Principalmente se utilizan corticoides tópicos y antibióticos orales (tetraciclinas y eritromicina). Se ha vinculado en escasas publicaciones con el desarrollo de linfoma cutáneo y como síndromes paraneoplásicos, por lo que se sugiere realizar seguimiento.
Chronic lichenoid pityriasis (PLC) is a benign disorder, characterized by a gradual course with the appearance of multiple squamous papules with adherent scales predominating in the trunk and proximal extremities. With the objective to describe its clinical presentation, diagnosis, differential diagnosis, treatment and review literature, we present an 88-yearold male with multiple lesions in the lower extremities of one year of evolution, with papules and adherent scales. A skin biopsy was performed that confirmed the diagnosis of PLC. The patient received treatment with moisturizing emulsion, clobetasol topical and clarithromycin with complete resolution of the lesions. Chronic lichenoid pityriasis is a rare inflammatory disease of unknown etiology that occurs most commonly in young adults and children. Although the clinic is suggestive, a skin biopsy is required for diagnostic confirmation. It is a benign disorder, often asymptomatic and self-limiting, so its patientto- patient treatment should be assessed. Topical corticosteroids and oral antibiotics (tetracyclines and erythromycin) are used. It has been linked in few publications with the development of cutaneous lymphoma and as paraneoplastic syndromes, so it is suggested to follow up.
Subject(s)
Humans , Male , Aged, 80 and over , Pityriasis Lichenoides/diagnosis , Pityriasis Lichenoides/pathology , Biopsy , Clobetasol/administration & dosage , Chronic Disease , Treatment Outcome , Pityriasis Lichenoides/drug therapy , Clarithromycin/administration & dosage , Anti-Inflammatory Agents/administration & dosage , Anti-Bacterial Agents/administration & dosageABSTRACT
Pityriasis lichenoides et varioliformis acuta (PLEVA), pityriasis lichenoides chronica (PLC) and febrile ulceronecrotic Mucha-Habermann disease (FUMHD) are considered different manifestations of the same disease. Febrile ulceronecrotic Mucha-Habermann disease is a rare, and potentially lethal illness which is characterized by fast progression of numerous papules that converge, ulcerate and form a plaque with a necrotic center, together with hemorrhagic vesicles and pustules that are associated with high fever and variable systemic symptoms. We report a 16 years old male presenting with erythematous papules with crusts and fever. The diagnosis of febrile ulceronecrotic Mucha-Habermann disease was confirmed with the pathological study of the lesions. He was successfully treated with minocycline after a failed attempt of treatment with prednisone.
Subject(s)
Humans , Male , Adolescent , Prednisone/therapeutic use , Pityriasis Lichenoides/drug therapy , Herpes Simplex/drug therapy , Anti-Inflammatory Agents/therapeutic use , Minocycline/therapeutic use , Skin Ulcer/pathology , Treatment Outcome , Pityriasis Lichenoides/pathology , Herpes Simplex/pathologyABSTRACT
The etiology of pityriasis lichenoides is unknown. One of the accepted theories admits that PL is an inflammatory response to extrinsic antigens such as infectious agents, drugs and vaccines. In recent medical literature, only the MMR vaccine (Measles, Mumps and Rubella) was associated with the occurrence of this disease. We present a case of a male, 12 year old healthy patient who, five days after Infl uenza vaccination, developed erythematous papules on the trunk, abdomen and limbs, some with adherent crusts and associated systemic symptoms. This case report is notable for describing the first case of pityriasis lichenoides et varioliformis acuta associated with the vaccine against Influenza.
.Subject(s)
Child , Humans , Male , Influenza Vaccines/adverse effects , Pityriasis Lichenoides/etiology , Epidermis/pathology , Erythema/drug therapy , Erythema/etiology , Erythema/pathology , Pityriasis Lichenoides/drug therapy , Pityriasis Lichenoides/pathologyABSTRACT
A doença de Mucha-Habermann ulceronecrótica febril (FUMHD) é uma variante clínica rara da pitiríase liquenoide variceliforme aguda (PLEVA). Tem etiologia incerta e é caracterizada por lesões úlceronecróticas, associadas a sintomas sistêmicos. Relata-se um caso de paciente masculino, com início agudo de lesões máculo-papulares, vesicobolhosas e úlceronecróticas, associadas à febre alta e mialgia. Tratado com prednisona 0,5 mg/kg/dia, obteve-se excelente resposta terapêutica. A FUMHD é uma variante severa da PLEVA, cujo diagnóstico é clínico e histopatológico. Vários tratamentos são descritos, tais como: metrotexate, corticoesteroides, PUVA, mas nenhum foi estabelecido.
The Febrile Ulceronecrotic Mucha-Habermann (FUMHD) disease is a rare variant of pityriasis lichenoides et varioliformis acuta (PLEVA). Its etiology still remains unknown and it is characterized by a sudden onset of ulceronecrotic skin lesions associated with systemic symptons. It is reported here the case of a male patient with a sudden and acute evolution of macules and papules, ulceronecrotic and vesicle-bullous lesions associated with systemic symptons. The patient was treated with prednisone 0,5 mg/kg/day with a dramatic response. The FUMHD is a severe variant of PLEVA and its diagnosis is clinical and histopathological. Many treatments such as methotrexate, corticosteroids and PUVA have been described .However, none of them has been settled.
Subject(s)
Humans , Male , Middle Aged , Glucocorticoids/therapeutic use , Herpes Simplex/drug therapy , Pityriasis Lichenoides/drug therapy , Prednisone/therapeutic use , Herpes Simplex/pathology , Pityriasis Lichenoides/pathology , Treatment OutcomeABSTRACT
En los niños, enfermedades como la psoriasis, dermatitis atópica o pitiriasis liquenoide son enfrentadas inicialmente con tratamientos tópicos; sin embargo, cuando éstos fallan, las siguientes opciones terapéuticas tienen importante efectos adversos (metotrexato, ciclosporina, acitretin), situación en la cual se presenta la fototerapia como una alternativa posible. Recientemente, el uso selectivo de luz ultravioleta centrado en un rango de longitud de onda entre 310-311 nm (UVB-banda angosta) ha demostrado ser más efectivo y menos eritematógeno que la fototerapia convencional de banda ancha.
Subject(s)
Humans , Female , Child , Dermatitis, Atopic/drug therapy , Skin Diseases/drug therapy , Phototherapy , Pityriasis Lichenoides/drug therapy , PUVA Therapy , Vitiligo/drug therapyABSTRACT
La pitiriasis liquenoide (PL) es una enfermedad poco frecuente y de etiología desconocida. Tiene dos formas clínicas que constituyen puntos extremos de presentación: PL aguda y crónica. El diagnóstico está basado en la sospecha clínica y el estudio histopatológico; no se dispone hasta el momento de un tratamiento curativo. El seguimiento periódico de estos pacientes es fundamental debido a la posibilidad de transformación hacia procesos linfoproliferativos. Presentamos once pacientes con diagnóstico clinicopatológico de PL, nueve de los cuales eran de sexo femenino. En cuatro casos pudimos deducir el motivo de las confusiones diagnósticas que demoraron el diagnóstico de estas presentaciones inusuales